[five_sixth last=”yes” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_color=”” background_image=”” background_repeat=”no-repeat” background_position=”left top” border_size=”0px” border_color=”” border_style=”” padding=”” margin_top=”” margin_bottom=”” animation_type=”” animation_direction=”” animation_speed=”0.1″ class=”” id=””]

Biocatalysis

Biocatalysis is the use of natural catalysts (enzymes) to produce chemical transformations in organic compounds. The enzymes used in this type of reaction can be isolated, purified or in cellular extracts, or in the interior of whole cells.

The use of these natural catalysts offers three major benefits against the use of traditional synthesis procedures:

  • They provide higher reaction speeds at lower concentrations, due to their high efficiency.
  • They offer greater specificity.
  • They carry out their function in an aqueous medium, minimising the use of organic solvents and reducing waste that is harmful to the environment.
[/five_sixth]
Biocataliss Schema
[five_sixth last=”yes” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_color=”” background_image=”” background_repeat=”no-repeat” background_position=”left top” border_size=”0px” border_color=”” border_style=”” padding=”” margin_top=”” margin_bottom=”” animation_type=”” animation_direction=”” animation_speed=”0.1″ class=”” id=””]

At PLASMIA we have designed and carried out various biocatalytic processes for the synthesis of nucleoside analogues and other APIs. Some of the enzymes used in these processes have been developed by our technical team using their experience in microbiology and molecular biology for cloning and expression of proteins.

The current production of nucleoside analogues through chemical methods requires numerous synthesis steps that make this procedure a very complicated and costly process. PLASMIA has developed a technology that allows the synthesis of these molecules via chemo-enzymatic means that simplify the current production process, costs and the amount of waste generated.
The process developed by PLASMIA is based on a reaction of exchange of nitrogenated bases catalysed by own enzymes:

[/five_sixth]
[five_sixth last=”yes” spacing=”yes” center_content=”no” hide_on_mobile=”no” background_color=”” background_image=”” background_repeat=”no-repeat” background_position=”left top” border_size=”0px” border_color=”” border_style=”” padding=”” margin_top=”” margin_bottom=”” animation_type=”” animation_direction=”” animation_speed=”0.1″ class=”” id=””]

PLASMIA’s objective is to apply its technology to the improvement of production processes for nucleoside analogues on an industrial scale to provide raw materials for the pharmaceutical industry. The obtaining of analogue nucleosides with this technology represents greater speed of synthesis, a reduction in costs and lower production of waste, thus reducing its environmental impact.

[/five_sixth]